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KMID : 0828520090130010007
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Journal of the Korean Geriatrics Society
2009 Volume.13 No. 1 p.7 ~ p.15
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Effects of Angiotensin-Converting Enzyme Inhibitor on Arterial Stiffness, Diastolic Function, and Exercise Performance in Patients with Hypertension
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Kim Kye-Hun
Park Jong-Chun
Oh Chun-Soon
Choi Seung-Hee
Kim Mi-Ran
Lee Woo-Seok
Yoon Hyun-Ju
Ahn Young-Keun
Jeong Myung-Ho
Cho Jeong-Gwan
Kang Jung-Chaee
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Abstract
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Background: The aim of this study was to investigate the relations between arterial stiffness, diastolic function, and exercise performance and the effects of angiotensin-converting enzyme inhibitor(ACEI), perindopril, in these three areas in patients with hypertension(HT).
Methods: A total of 39 patients(60.9±4.9 years, 23 males) with a newly diagnosed or untreated HT, stage I, were enrolled. Arterial stiffness measured by pulse wave velocity, diastolic function measured by echocardiography, and exercise performance and hemodynamic parameters measured by a treadmill exercise test were compared before and after 6 months of medical treatment with an ACEI.
Results: The parameters for arterial stiffness, diastolic function, and exercise performance did not show significant correlations with each other at baseline. Systolic(from 147.6±6.5mmHg to 134.3±9.6mmHg, p<0.001) and diastolic blood pressures(from 87.7±7.5mmHg to 82.9±6.2mmHg, p<0.001) decreased significantly after 6 months of ACEI treatment. Except for duration of total exercise time, the parameters for arterial stiffness, diastolic function, and the hemodynamic response to exercise also improved significantly after 6 months of ACEI treatment.
Conclusion: Though the parameters for arterial stiffness, diastolic function, and exercise performance were not asso- ciated with each other at baseline, they all improved significantly after 6 months of medical treatment with an ACEI in elderly patients with stage I HT. The results of this study suggest the possibility of additional benefits of ACEI beyond lowering blood pressure.
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KEYWORD
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Arterial stiffness, Diastolic function, Exercise performance
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